SCIENTIFIC POSTER
ThioBridge™ as a Tool for the Design, Optimization & Manufacture of ADCs
The ThioBridge conjugation technology makes use of naturally occurring interchain disulfide bonds of an antibody to generate antibody drug conjugates (ADCs). ThioBridge offers several key features including homogeneity with high conversion to a single DAR species, stability as the linker does not deconjugate or cross-conjugate and site-specificity due to conserved location of conjugation.
What’s Inside?
The ThioBridge linker technology forms a stable and homogeneous conjugate at the naturally occurring interchain disulfide bonds of an antibody. The location proximal to the hinge region can sterically shield the Fcy receptor binding sites thereby widening the TI by reducing the off-target toxicities that are observed in the marketed ADCs. Download the scientific poster to learn more.